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KMID : 1189420120250010012
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2012 Volume.25 No. 1 p.12 ~ p.21
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The Effects of Hyunggaeyungyo-tang of Suppression of iNOS Production on Mice with Allergic Rhinitis
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Park Jung-Hoon
Hong Seung-Ug
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Abstract
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Background and Objectives: Allergic rhinitis is one of the most common diseases in the otorhinolaryngology area. in oriental clinic, Hyunggaeyungyo-tang(HYT) has been used as a primary prescription to treat allergic rhinitis. However, there have been no studies so far performed on the effect of this HYT use. The purpose of this study was find out therapeutic effects of its exclusive use on the rat with allergic rhinitis.
Material and Methods: Thirty BALB/c mice were divided into three group : normal group(NOR), control group(CON) inoculated with allergic rhinitis and sample group(SAM) treated with the HYT extract after it was treated the same as the control group. Rats were sensitized intraperitoneally with ovalbumin solution 4times at intervals of 2 days. After that time, rats in SAM were administered by HYT to treat the inflammation.
Results: 1. The number of eosinophil in SAM noticeably decreased than CON and this decrease had probability. The inhibition of eosinophil distribution. The infiltration of eosinophil in SAM noticeably decreased than CON. 2. The damaged mucosa as disruption of cilia in respiratory cell, vacant mucose secreting cell and infiltration of inflammation intricate cells in CON were increased than NOR, but SAM same as normal configuration. Decrease of icthing and sneezing intricate neurotransmitter (substance P). Decrease of angiogenesis intricate cytokine(MIP-2). 3. Transcription factor(NF- p65) was decreased. 4. Transcription factor inhibitor(p-) was decreased. 5. Inflammation cytokine(iNOS) was decreased.
Conclusion: The results suggest that HYT is significantly effective in the treatment of inflammation caused by allergic rhinitis through the suppression of NF- activation and iNOS production.
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KEYWORD
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Hyunggaeyungyo-tang, allergic rhinitis, NF-, iNOS
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